
Mining millets
Millets are ancient grains and cereals with origins in Africa, the Middle East and Asian countries including China and India, where they are food staples. In addition to growing in harsh environments and enduring drought or attacks by pests, millets are often less processed and yield higher nutritional benefits than grains such as corn, rice and wheat.

Those conventional grains of the Western diet are well studied, but scientists know little about the bioactive food species in major and minor millets, including the distribution of , or fat-soluble compounds; the composition of , or lipid building blocks; and the presence of , or substances in millets and food that benefit physiological health.
Sugasini Dhavamani, a research assistant professor at the , and her team have studied the nutri-lipidomic profiles of major and minor millet seeds and oils.
“I am passionate about lipid research,” Dhavamani said, “I love working at the University of Illinois because we have amazing equipment and facilities, and great means for collaboration.”
The oils of grains are not commercially available, so the researchers first extracted lipids from the millets, then analyzed samples using high-performance liquid chromatography and gas chromatography-mass spectrometry.
“The oil extraction takes time,” Dhavamani said, adding that the researchers face other challenges. “After extraction we often get a low quantity of lipids, which can also cause difficulty. Stability is a concern because the lipids are easily oxidized.”

After profiling sorghum millet, little millet, finger millet, proso millet, kodo millet, pearl millet and foxtail millet, Dhavamani and colleagues found that oleic acid, linoleic acid and alpha-linoleic acid, or omega-9,-6 and -3, are the three major fatty acid species present in millets and seed oils.
“Most of the millets evaluated contained omega-9 and omega-6 and a small amount of omega-3 fatty acids, which help to lower cholesterol and blood pressure levels, and can benefit chronic disease,” Dhavamani said. “Millets also have nutraceuticals, which are helpful for lowering inflammation.”
In the future, the researchers want to expand this work into animal models, where Dhavamani can assess the health benefits of millet consumption, followed by examining proteomics and metabolomics of millets; however, experiments of this scale require increased funding.
Details
Sugasini Dhavamani will present this research from 5:30 to 6:30 p.m. CDT on Sunday, March 24, at 2024, the 偷拍偷窥 and 偷拍偷窥 Biology annual meeting in San Antonio. Her poster will be at board 326.
Abstract title: Nutri-lipidomics, bioactive lipids and antioxidant potential of major and minor millet seed and oil — a novel approach
Enjoy reading ASBMB Today?
Become a member to receive the print edition four times a year and the digital edition monthly.
Learn moreGet the latest from ASBMB Today
Enter your email address, and we鈥檒l send you a weekly email with recent articles, interviews and more.
Latest in Science
Science highlights or most popular articles

Neurobiology of stress and substance use
MOSAIC scholar and proud Latino, Bryan Cruz of Scripps Research Institute studies the neurochemical origins of PTSD-related alcohol use using a multidisciplinary approach.

Pesticide disrupts neuronal potentiation
New research reveals how deltamethrin may disrupt brain development by altering the protein cargo of brain-derived extracellular vesicles. Read more about this recent 偷拍偷窥 & Cellular Proteomics article.

A look into the rice glycoproteome
Researchers mapped posttranslational modifications in Oryza sativa, revealing hundreds of alterations tied to key plant processes. Read more about this recent 偷拍偷窥 & Cellular Proteomics paper.

Proteomic variation in heart tissues
By tracking protein changes in stem cell鈥揹erived heart cells, researchers from Cedars-Sinai uncovered surprising diversity 鈥� including a potential new cell type 鈥� that could reshape how we study and treat heart disease.

Parsing plant pigment pathways
Erich Grotewold of Michigan State University, an ASBMB Breakthroughs speaker, discusses his work on the genetic regulation of flavonoid biosynthesis.

Calcium channel linked to cancer drug resistance
Researchers discover a protein associated with carboplatin-resistant retinoblastoma, suggesting this protein could be a promising therapeutic target. Read more about this recent Journal of Biological Chemistry paper.